| 2022-02-19 15:15:00February 19, 2022 |   Avondale FC vs Bentleigh Greens SC | 3 - 1 | |
| 2022-02-25 19:30:00February 25, 2022 |  Melbourne Knights FC vs Avondale FC | 0 - 3 | |
| 2022-03-05 15:15:00March 5, 2022 |  Avondale FC vs St Albans Saints SC | 0 - 1 | |
| 2022-03-12 19:00:00March 12, 2022 |  Hume City FC vs Avondale FC | 0 - 3 | |
| 2022-03-19 15:15:00March 19, 2022 |  Avondale FC vs Green Gully SC | 1 - 0 | |
| 2022-03-26 15:00:00March 26, 2022 |  Eastern Lions SC vs Avondale FC | 2 - 4 | |
| 2022-04-02 19:00:00April 2, 2022 |  Dandenong Thunder FC vs Avondale FC | 2 - 1 | |
| 2022-04-08 20:30:00April 8, 2022 |  Oakleigh Cannons FC vs Avondale FC | 6 - 2 | |
| 2022-04-16 15:15:00April 16, 2022 |  Avondale FC vs Altona Magic SC | 3 - 0 | |
| 2022-04-23 17:30:00April 23, 2022 |  Port Melbourne Sharks SC vs Avondale FC | 0 - 2 | |
| 2022-04-30 15:15:00April 30, 2022 |  Avondale FC vs Dandenong City SC | 0 - 0 | |
| 2022-05-07 15:15:00May 7, 2022 |  Avondale FC vs Heidelberg United FC | 1 - 3 | |
| 2022-05-13 19:30:00May 13, 2022 |  South Melbourne FC vs Avondale FC | 4 - 3 | |
| 2022-05-20 20:30:00May 20, 2022 | Bentleigh Greens SC vs Avondale FC | 1 - 1 | |
| 2022-05-28 15:15:00May 28, 2022 | Avondale FC vs Melbourne Knights FC | 1 - 1 | |
| 2022-06-05 15:00:00June 5, 2022 | St Albans Saints SC vs Avondale FC | 0 - 3 | |
| 2022-06-11 15:15:00June 11, 2022 | Avondale FC vs Hume City FC | 4 - 3 | |
| 2022-06-17 20:00:00June 17, 2022 | Green Gully SC vs Avondale FC | 1 - 1 | |
| 2022-06-25 15:15:00June 25, 2022 | Avondale FC vs Eastern Lions SC | 5 - 1 | |
| 2022-07-02 15:00:00July 2, 2022 | Avondale FC vs Dandenong Thunder FC | 0 - 1 | |
| 2022-07-09 15:00:00July 9, 2022 | Avondale FC vs Oakleigh Cannons FC | 1 - 4 | |
| 2022-07-16 18:00:00July 16, 2022 | Altona Magic SC vs Avondale FC | 0 - 1 | |
| 2022-07-26 20:00:00July 26, 2022 | Avondale FC vs Port Melbourne Sharks SC | 1 - 2 | |
| 2022-07-30 16:45:00July 30, 2022 | Dandenong City SC vs Avondale FC | 3 - 1 | |
| 2022-08-14 15:00:00August 14, 2022 | Heidelberg United FC vs Avondale FC | 1 - 4 | |
| 2022-08-21 15:00:00August 21, 2022 | Avondale FC vs South Melbourne FC | 0 - 1 | |
